Inhibition of Human Epidermal Growth Factor Receptor-2 (HER-2) from Pomelo (Citrus maxima) Flavonoid Compounds: an In Silico Approach

Citrus maxima or pomelo is a plant that has potential as an anticancer because it contains flavonoids. One of the targets breast receptors HER-2 protein. This research aims to determine activity, toxicity compound, and prediction physicochemical properties flavonoids contained in through silico approach. Flavonoid compounds were screened using SwissADME with Lipinski's rule five, Torsion, TPSA, P-Gp Non-Substrate. Compounds passed screening carried out molecular docking receptor (PDB ID: 3PP0) Molegro Virtual Docker (MVD). The (GDP was declared valid had RMSD<2Å. results showed there 11 flavonoid lower rerank score than comparison compound Trastuzumab. Toxicity predicted Protox II online tool safe limits, namely classes 5 3. Based on this research, can be concluded acacetin, diosmetin, honyucitrin, isosinensetin, nobiletin, sinensetin, tangeretin candidates for cancer drugs based natural ingredients.Keywords: cancer, maxima, HER-2, silico.